CURRENT RESEARCH INTERESTS

The projects in our lab are described below. Please visit the linked study pages on clinicaltrials.gov for additional information:

  • Investigating racial differences in neurovascular function in response to high dietary salt.

    • The primary focus of Dr. Robinson’s NIH Career Development Award is on determining whether there are racial differences in the cardiovascular responses to a high salt meal (NCT04244604).

    • We have a pending study focused on a hydration intervention (with or without dietary potassium) to improve blood pressure regulation and cardiometabolic health in young Black adults (NCT06062017).

  • Determining the role of health behaviors, such as exercise, diet, and sleep, in contributing to blood vessel function and neural control of blood pressure.

    • We have an ongoing study focused on short-term sleep extension as a feasible strategy to improve cardiometabolic health and appetite regulation young adults who report inadequate sleep (NCT05918744).

    • We have an ongoing study focused on the ability of concomitant ketone supplementation to counteract the potential adverse effects of short-term high salt on blood vessel function, blood pressure regulation, and kidney function (NCT05545501).

  • Investigating the contribution of oxidative stress (high levels of free radicals) on blood vessel function autonomic control of the circulation.

    • We have two ongoing studies examining the acute and short-term ability of the mitochondrial-targeted antioxidant MitoQ to improve measures of cardiovascular health (NCT04334135 & NCT05561556).

SELECTED PUBLICATIONS

Some of our recent publications are presented below. Each title is hyperlinked.

1.    Linder BA, Stute NL, Hutchison ZJ, Barnett AM, Tharpe MA, Kavazis AN, Kirkman DL, Gutiérrez OM, Robinson AT. Acute high dose MitoQ does not increase urinary kidney injury markers in healthy adults. Am J Physiol Renal Physiol. 2023 Nov 9. doi: 10.1152/ajprenal.00186.2023. Epub ahead of print.

2.    Jeong S, Hunter SD, Cook MD, Grosicki GJ, Robinson AT. Salty subjects: unpacking racial differences in salt-sensitive hypertension. Curr Hypertens Rep. 2023 Oct 25. doi: 10.1007/s11906-023-01275-z. Online ahead of print. PMID: 37878224

3.    Tharpe MA, Linder BA, Babcock MC, Watso JC, Pollin KU, Hutchison ZJ, Barnett AM, Culver MN, Kavazis AN, Brian MS, Robinson AT. Adjusting for muscle strength and body size attenuates sex differences in the exercise pressor reflex in young adults. Am J Physiol Heart Circ Physiol. 2023 Dec 1;325(6):H1418-H1429.

4.    Robinson AT, Linder BA, Barnett AM, Jeong S, Sanchez SO, Nichols OI, McIntosh MC, Hutchison ZJ, Tharpe MA, Watso JC, Gutiérrez OM, Fuller-Rowell TE. Cross-sectional analysis of racial differences in hydration and neighborhood deprivation in young adults. Am J Clin Nutr. 2023 Oct;118(4):822-833.

5.    Watso JC, Fancher IS, Gomez DH, Hutchison ZJ, Gutiérrez OM, Robinson AT. The damaging duo: Obesity and excess dietary salt contribute to hypertension cardiovascular disease. Obesity Reviews. 2023 Aug;24(8):e13589.

6.    Grosicki GJ, Flatt AA, Cross BL, Vondrasek JV, Blumenberg WT, Lincoln ZR, Chall A, Bryan A, Patel RP, Ricart K, Linder BA, Sanchez SO, Watso JC, Robinson AT.  Acute Beetroot Juice Reduces Blood Pressure in Young Black and White Males but not Females. Redox Biol. 2023 Jul;63:102718.

7.    Linder BA, Babcock MC, Migdal KU, Watso JC, Robinson AT. Short-term high dietary salt intake does not influence resting or exercising heart rate variability but increases MCP-1 concentration in healthy young adults. Am J Physiol Regul Integr Comp Physiol. 2023 May 1;324(5):R666-R676

8.    Barnett AM, Babcock MC, Watso JC, Migdal, KU, Gutiérrez OM, Farquhar WB, Robinson AT. High dietary salt intake increases urinary NGAL excretion and creatine clearance in healthy young adults. Am J Physiol Renal Physiol. 2022 Apr 1;322(4):F392-F402.